USE
Colchicine has FDA
approval for gout prophylaxis and treatment of acute gouty flares. It
also has approval for the treatment of familial Mediterranean fever.
Colchicine has been used off-label to treat several other conditions,
including hepatic cirrhosis, primary biliary cirrhosis, and pseudogout
SIDE EFFECT
Digestive disorders (diarrhoea, nausea, vomiting), urticaria, skin rashes.
PRECAUTION
Colchicine should not be used in patients with hepatic or renal impairment who are also taking CYP3A4 and P-glycoprotein inhibitors.
Patients need to be informed of the symptoms of overdose and encouraged
to seek medical assistance if they have concerns about the amount they
have taken.